GroEL is an immunodominant surface-exposed antigen of Rickettsia typhi
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منابع مشابه
Surface Proteome Analysis and Characterization of Surface Cell Antigen (Sca) or Autotransporter Family of Rickettsia typhi
Surface proteins of the obligate intracellular bacterium Rickettsia typhi, the agent of murine or endemic typhus fever, comprise an important interface for host-pathogen interactions including adherence, invasion and survival in the host cytoplasm. In this report, we present analyses of the surface exposed proteins of R. typhi based on a suite of predictive algorithms complemented by experiment...
متن کاملHeterogeneity of CD4-positive human T-cell clones which recognize the surface protein antigen of Rickettsia typhi.
Immunity to the typhus group of rickettsiae is largely dependent on the effector function of several classes of T lymphocytes, including those which produce gamma interferon. Since the surface protein antigen (SPA) derived from typhus group rickettsiae has been shown to be an effective immunogen in animal models, human T-cell clones specific for the SPA of Rickettsia typhi were isolated and tes...
متن کاملProperties of quinoxaline oxide-resistant Rickettsia typhi.
Weiss, Emilio (Naval Medical Research Institute, Bethesda, Md.) and Harry R. Dressler. Properties of quinoxaline oxide-resistant Rickettsia typhi. J. Bacteriol. 83:415-417. 1962.-An effort was made to apply to the Wilmington strain of Rickettsia typhi the observation that in certain strains of rickettsiae and viruses of the psittacosis group quinoxaline oxide resistance is easily obtained and i...
متن کاملIsolation of Rickettsia typhi from Human, Mexico
To the Editor: Murine typhus is a febrile illness caused by Rickettsia typhi. The clinical manifestations are nonspecific, and the signs and symptoms resemble those of several other febrile illnesses. Murine typhus can be a self-limiting infection; however, it should be diagnosed and treated because complications and even death can result (1). In Mexico, particularly in Yucatan State, cases of ...
متن کاملThe C-terminal domain of Salmonella enterica serovar typhimurium OmpA is an immunodominant antigen in mice but appears to be only partially exposed on the bacterial cell surface.
We examined the way the major outer membrane protein OmpA of Salmonella enterica serovar Typhimurium is recognized by the mouse immune system, by raising a panel of 12 monoclonal antibodies (MAbs) against this protein. Interaction between OmpA and these MAbs is competitively inhibited with several-hundredfold dilutions of mouse polyclonal sera obtained by immunization with live or heat-killed w...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2021
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0253084